Frontal cortical control of posterior sensory and association cortices through the claustrum
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(02/02/2024, 10:19:21 )
CLA connections: Anterior Cingulate Cortex (ACC)
“Executive cortices such as the anterior cingulate cortex (ACC) are heavily interconnected with claustrum (Smith and Alloway 2010; White et al. 2017; Wang et al. 2017; Atlan et al. 2017). In addition, activation of afferents from ACC, but not sensory cortices, drives action potential firing of claustrum spiny projection neurons (White et al. 2018)” (White and Mathur, 2018, p. 2999)
“In this study, we show that the claustrum provides a functional anatomical link between frontal cortices, specifically ACC, and posterior sensory/association cortices (i.e., V1/V2 and PtA).” (White and Mathur, 2018, p. 3003)
Top-down signals from frontal cortices
“described herein supports a model wherein the claustrum processes and propagates top-down signals arising from frontal cortices to coordinate cortical activity of hierarchically lower cortices (Mathur 2014)” (White and Mathur, 2018, p. 3004)
“Taken together, the cortico-claustro-cortical circuitry described herein represents a previously unrecognized system in brain positioned to enable spatiotemporal control of distributed cortical sites. While further work is needed to fully understand how claustrum neurons that are driven by the ACC are, in turn, controlling cortical areas such as PtA and V1/V2, the present data provide a novel top-down system that may undergo perturbation in neuropsychiatric illness (Morys et al. 1996; Cascella et al. 2011).” (White and Mathur, 2018, p. 3005)