Psylocibin decreases amplitude and variance as well as functional connectivity
“Psilocybin significantly decreased both the amplitude of low frequency fluctuations as well as the variance of BOLD signal in the left and right claustrum. Psilocybin also significantly decreased functional connectivity of the right claustrum with auditory and default mode networks (DMN), increased right claustrum connectivity with the fronto-parietal task control network (FPTC), and decreased left claustrum connectivity with the FPTC.” (Barrett et al., 2020, p. 1)
“Subjective effects of psilocybin predicted changes in the amplitude of low frequency fluctuations and the variance of BOLD signal in the left and right claustrum.” (Barrett et al., 2020, p. 1)
“Psilocybin reduced measures of activity (variance and amplitude of low-frequency fluctuations) of both left and right claustrum during the acute effects of psilocybin, and led to alterations in both left and right claustrum connectivity with brain networks that support sensory and cognitive processes. Subjective effects (overall strength of drug effect, as well as mystical experience and/or ineffability scores while controlling for overall strength of drug effects) were associated with decreases in variance and ALFF of the claustrum, but not the flanking brain structures of the insula or putamen.” (Barrett et al., 2020, p. 7)
“Activity and connectivity of both visual (Roseman et al., 2016; Carhart-Harris et al., 2016b; Kaelen et al., 2016) and auditory (Barrett et al., 2017) sensory cortices are also associated with the strength of sensory effects of psychedelic drugs.” (Barrett et al., 2020, p. 7)
“These analyses also demonstrate decreased connectivity between left claustrum and the FPTC, as well as a negative association between left claustrum connectivity with the FPTC and modularity of this network. Together, the present findings support the notion that the claustrum may be involved at a circuit-level to exert psilocybin-induced disruptions in both the DMN and task-positive networks.” (Barrett et al., 2020, p. 8)
“Identified associations are specific to the right and left claustrum and are not reflected in the insula or the putamen, providing evidence supporting the hypothesis that disruption of claustrum function may be associated with subje